Minimally invasive diagnosis of neurodegenerative disorders

Minimally invasive tests for the accurate diagnosis of Lewy Body Dementia and Parkinson’s Disease

Neurodegenerative damage begins years or even decades before disease symptoms develop. Currently, the diagnosis of neurodegenerative disorders is based upon often lengthy clinical assessment once symptoms are established and irreversible neuronal loss has occurred. Available diagnostic tools, such as PET scanning and cerebrospinal fluid (CSF) testing are expensive and invasive for the patient, and therefore not commonly used. Differentiating one neurodegenerative disorder from another is also challenging, due to the overlapping symptoms.

ESPDx is developing scalable liquid-biopsy tests based upon measurements of disease specific biomarkers in Extracellular Vesicles (EVs) purified from blood and saliva. Our technology provides superior sensitivity and specificity, allows detection of early stages of neurological disorders such as the Lewy Body Disorders (Parkinson’s Disease and Lewy Body Dementia) and a differential diagnosis of Alzheimer’s.

We can support Biotechnology and Pharmaceutical companies developing disease-modifying therapies in pre-clinical development, in stratifying patients for clinical trials, and in monitoring disease progression. Ultimately meaning that the right drugs can reach the right patients faster.

Adding value through the drug development process

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Our science

First GFX

ESPDx products and services are based upon extensive research into the role of Extracellular Vesicles (EVs) in Lewy Body Disorders (LBD) pathobiology*. EVs are very small nanometre-sized particles produced by all cells. EVs are present in body fluids such as blood, saliva and CSF. ESPDx have identified that EVs derived from LBD samples carry changes associated with LBD, including the enrichment of disease specific proteins and lipids. Based on the identification of these disease biomarkers, ESPDx scientists are developing minimally invasive, scalable and accurate laboratory tests for early detection of LBD in blood and saliva.

*Kurzawa-Akanbi et al. Altered ceramide metabolism is a feature in the extracellular vesicle-mediated spread of alpha-synuclein in Lewy body disorders. Acta Neuropathol. 2021. PMID: 34514546.

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For Clinicians
  • Early interventions
  • Improved patient management
  • Correct medication
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For patients
  • Lifestyle adjustments
  • Correct Medication
  • Reduced anxiety
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For Pharma & Biotech
  • Patient stratification
  • Track disease progression
  • Surrogate clinical endpoints

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About Lewy Body Dementia

Lewy body dementia is the second most common type of neurodegenerative dementia in older people. At least 10-15% of all people who live with dementia have Lewy body dementia.

The main features or symptoms of Lewy body dementia include: Cognitive impairment, visual hallucinations, fluctuations in attention, REM sleep disturbance and Parkinson’s symptoms.

Changes in memory are not always present earlier in the condition.

From www.lewybody.org

ESPDX half page About Lewy Body Dementia

Partnering

At ESPDx we are always open to discussing new business opportunities and collaborative partnerships which align with our corporate strategy.

We would welcome a meeting or a call to start a conversation.

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Get in touch

The Biosphere
Draymans Way
Newcastle upon Tyne
NE4 5BS
United Kingdom

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